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RESEARCH AREA

The team's research mainly focuses on the areas: mechanisms of tumor metastasis and targeted therapy, the pathogenesis of high-risk HPV-induced cervical cancer, its precancerous lesions screening, early intervention of cervical cancer and ovarian cancer’s molecular typing

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The Fruits of Our Labor

PUBLISHED WORK

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GENOME-WIDE PROFILING OF HPV INTEGRATION IN CERVICAL CANCER IDENTIFIES CLUSTERED GENOMIC HOT SPOTS AND A POTENTIAL MICROHOMOLOGY-MEDIATED INTEGRATION MECHANISM

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A GENOME-WIDE ASSOCIATION STUDY IDENTIFIES TWO NEW CERVICAL CANCER SUSCEPTIBILITY LOCI AT 4Q12 AND 17Q12

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TUMOR-ASSOCIATED LYMPHATIC ENDOTHELIAL CELLS PROMOTE LYMPHATIC METASTASIS BY HIGHLY EXPRESSING AND SECRETING SEMA4C

3D Scans

TALEN-MEDIATED TARGETING OF HPV ONCOGENES AMELIORATES HPV-RELATED CERVICAL MALIGNANCY

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SIX1 PROMOTES TUMOR LYMPHANGIOGENESIS BY COORDINATING TGFBETA SIGNALS THAT INCREASE EXPRESSION OF VEGF-C

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MIR-9 REGULATION OF BRCA1 AND OVARIAN CANCER SENSITIVITY TO CISPLATIN AND PARP INHIBITION

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ACHIEVEMENTS

The Story of our LAB

In the recent years, the team of gynecologic oncology led by Professor Ma has been responsible for 1 project (chief unit) of 973 National Projects, 2 projects of National 863 Projects, and got more than 30 million yuan funded by the National Natural Science Foundation of China, 2 projects of the National Outstanding Youth Fund and 2 projects of Overseas Youth Cooperation (Outstanding Youth Fund B), 15 projects of National Natural Science Foundation of China and 39 provincial or ministerial projects. He has published 739 papers (including 65 papers of SCI and more than 1000 papers cited by SCI) in domestic and foreign core journals. He has published 18 monographs, won 3 second prizes of national science and technology progress awards, 1 first prize of scientific and technological progress in Hubei Province, 1 Provincial Achievement Promotion Award, won 7 national invention patents, and declared 2 international patents.

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RESEARCH EQUIPMENT

Embryonic Stem Cells

ELECTRON MICROSCOPE

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CELL
CULTURE

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IVIS SPECTRUM
SYSTEM

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FLUORESCENCE MICROSCOPE

Petri Dish

FLOW
CYTOMETER

Embryonic Stem Cells

REAL-TIME PCR
INSTRUMENT

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ULTRA-COLD
FREEZER

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LAMINAR FLOW
ROOM

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TEAM LEADER

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DING MA

Professor

&

Academician

  A Secondary professor at HUST, an academician of Chinese Academy of Engineering, a director of the Department of Obstetrics and Gynecology at Tongji Hospital, Tongji medical college of HUST, and a director of the Ministry of Education's key laboratory for tumor invasion and metastasis, a Vice Chairman of the Asia-Pacific Society of Gynecologic Oncology, a Chairman of the Chinese Medical Association Gynecological Oncology Branch, a Director of the National Center for Obstetric and Gynecological Diseases and Clinical Medicine, a Director of the China Association for the Promotion of International Exchange of Health Care, an Honorary Chairman of the Association of Obstetrics and Gynaecologists of Hubei Medical Doctor Association, the first recipient of the National Outstanding Youth Fund in the obstetrics and gynecology community in China (2000) and the chief scientist of the "973" project (2002).

  Prof MA was chiefly responsible for editing the diagnosis and treatment guidelines of gynecological malignancy, an editor of the Gynecology and Obstetrics( national planning textbook for medical students of eight-year training system) and the English version of it, published 486 papers as the first author or correspondent author among which 163 papers were published in the SCI journals represented by Nature Genetics, J Clin Invest and J Exp Med, with a total impact factor of 612.7, cited by others for totaling 4262 times including some cited by Lancet or other international journals for 2630 times ,led the Department of Obstetrics and Gynecology of Tongji Hospital to be honored as a National Key Disciplines for two times(a National Excellent Course in 2009 and a National Key Clinical Specialization of the Ministry of Health in 2010), also led the research team and lab to be awarded the title of Innovative Team of the Ministry of Education in 2006 and Key Lab of the Ministry of Education in 2008 respectively and they were authorized as the National Center for Obstetrics and Gynecology Clinical Medicine Research.

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Dr.Ma EVERYWHERE

Dr. Ma in office

Dr. Ma in lab

Dr. Ma in ward

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CORE TEAM MEMBERS

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Science Researcher

Principle Investigator & Professor

DR. SHIXUAN WANG

A secondary professor, a Chief physician, Ph.D. Supervisor, Distinguished Professor of Chutian Scholars, entitled to a special allowance from Hubei Provincial Government, currently serving as the Deputy Director of Obstetrics and Gynecology, Tongji Hospital Affiliated Tongji Medical College of HUST, a Director of the Department of Gynaecology, a Deputy Director of the National Obstetrics and Gynecology Diseases Clinical Center, a Deputy Director of the Ministry of Education and Hubei Provincial Key Laboratory of Tumor Invasion and Metastasis, a Secretary general of gynecological oncology branch of Chinese medical association, a chairman of Gynecology and Obstetrics branch of Hubei Medical Association, a vice chairman of the Women and Children’s Professional Committee of China International Medical Exchange Association, and a director of Women’s Pelvic Reproductive Health Quality Control Center of Hubei Province.

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A LOT OF

      GREAT SCIENTISTS

                              IN OUR LAB

Our team is bigger than you may think and a lot of scientists contribute to this great career.

NEW RESEARCH                                COLLABORATION                                                                    ESTABLISHED

University of Texas MD Anderson Cancer Center

&

Department of Obstetrics and Gynecology, Tongji Hospital,
Tongji Medical College, Huazhong University of Science and Technology

CHINESE

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                          IN INTERNATIONAL MEETING

Chinese gynecologic oncologic team from our lab reported our meaningful results in the annual SGO meeting and gained a lot of attention due to great achievements we have made

OTHERS

PATENT I

the method of applying cervical cancer associated SNPs to detecting individuals susceptible for cervical cancer; Approval year: 2013; Patent no: ZL 2013 1 0230764.5

PATENT II

the Acquisition and Application of a novel polypeptide TMVP1 specifically targeting tumor lymphatics; Approval year: 2014; Patent no: ZL 2014 1 0041476.X

PATENT III

the preparation method of one kind of nanoparticle for treating HPV infection; Approval year: 2015; Patent no: 201510999391.7

PATENT IV

the method for knocking out HPV E6E7 oncogene using TALEN; Approval year: 2015; Patent no: 201410719340.X

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SERVICES

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harmonious atmosphere

Exceeding Expectations

quiet environment

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CONTACT US

Tongji Hospital of Tongji Medical College,
Huazhong University of Science and Technology,
No.1095 Jie Fang Avenue, Hankou, Wuhan 430030, P.R. China.

+86 13871143350

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